Article
Phosphodiesterase-10A Inverse Changes in Striatopallidal and Striatoentopeduncular Pathways of a Transgenic Mouse Model of DYT1 Dystonia.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Feb 2017
D'Angelo Vincenza, Castelli Valentina, Giorgi Mauro, Cardarelli Silvia, Saverioni Ilaria, Palumbo Francesca, Bonsi Paola, Pisani Antonio, Giampà Carmela, Sorge Roberto, Biagioni Stefano, Fusco Francesca R, Sancesario Giuseppe
Abstract excerpt
We report that changes of phosphodiesterase-10A (PDE10A) can map widespread functional imbalance of basal ganglia circuits in a mouse model of DYT1 dystonia overexpressing mutant torsinA. PDE10A is a key enzyme in the catabolism of second messenger cAMP and cGMP, whose synthesis is stimulated by D1 receptors and inhibited by D2 receptors preferentially expressed in striatoentopeducuncular/substantia nigra or...
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