Article

<i>G</i> α <i> <sub>olf</sub> </i> Regulates Biochemical Signaling in Neurons Associated with Movement Control and Initiation

2024-04-05

Abstract excerpt

The heterotrimeric G-protein α subunit, Gα olf , acts to transduce extracellular signals through G-protein coupled receptors (GPCRs) and stimulates adenylyl cyclase mediated production of the second messenger cyclic adenosine monophosphate. Numerous mutations in the GNAL gene, which encodes Gα olf , have been identified as causative for an adult-onset dystonia. These mutations disrupt GPCR signaling cascades in...

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Literature Corpus work: a59c2668-6f24-57d6-ad90-64d6c35b6d3c
DOI: 10.1101/2024.04.03.587766

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