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CipA mediates complement resistance of <i>Acinetobacter baumannii</i> by formation of a Factor I-dependent quadripartite assemblage

2022-02-17

Abstract excerpt

Multidrug-resistant Acinetobacter baumannii is known to be one of the leading pathogens that cause severe nosocomial infections. To overcome eradication by the innate immune system during infection, A. baumannii developed a number of immune evasion strategies. Previously, we identified CipA as a plasminogen-binding and complement-inhibitory protein. Here we show that CipA strongly inhibits all three complement a...

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Literature Corpus work
2ff35a4f-9b13-5605-9003-aa89e908a88a
DOI
10.1101/2022.02.17.480811
Open publication

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CipA mediates complement resistance of <i>Acinetobacter baumannii</i> by formation of a Factor I-dependent quadripartite assemblageDOI 10.1101/2022.02.17.480811
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