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Article

Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b.

European journal of immunology - 1 Mar 2014

Ho Derek K, Skurnik Mikael, Blom Anna M, Meri Seppo

Abstract excerpt

The outer membrane protein Ail of Yersinia pestis mediates several virulence functions, including serum resistance. Here, we demonstrate that Ail binds C4b-binding protein (C4BP), the primary fluid-phase regulator of the classical and lectin pathways. Non-covalent binding of C4 and C4b to Ail was also observed. C4BP bound to Ail can act as a cofactor to the serine protease factor I (fI) in the cleavage of...

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PMID: 24760758
DOI: 10.1002/eji.201343552

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