Article

The Core Subunit NDUFS2 in Mitochondrial Complex I is Critical to Oxygen Sensing in Human Ductus Arteriosus Smooth Muscle Cells

2025-07-14

Abstract excerpt

<h4>Background</h4> Mitochondria in ductus arteriosus smooth muscle cells (DASMCs) are oxygen sensors triggering vasoconstriction at birth; however, the oxygen sensing mechanisms are incompletely understood. Given the conserved role of mitochondrial Complex I subunit NDUFS2 in other oxygen-sensing tissues, we examined its role in DASMC oxygen sensing, comparing it to other Complex I subunits (NDUFS1 and NDUFS7) a...

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Literature Corpus work: 2fc2760b-4f13-5080-8844-78117cb608fa
DOI: 10.1101/2025.07.08.663799

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