Article

SQLE promotes osteosarcoma progression via activating TGFβ/SMAD signaling pathway

2024-08-16

Abstract excerpt

<title>Abstract</title> <p>The prognosis of advanced osteosarcoma (OS) has remained stagnant in last decades, requiring the identification of novel therapeutic targets. Recently, much attention was paid to the role of squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol metabolism, in the field of oncology. Here, we found the upregulation of SQLE in OS samples than that in normal tissues through data...

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Literature Corpus work: 778d657b-b3c7-58b8-9f8a-abad0f76e1aa
DOI: 10.21203/rs.3.rs-4743292/v1

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