Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signalling

Abstract excerpt

BACKGROUND AND PURPOSE: Squalene epoxidase (SQLE) is a key enzyme involved in cholesterol biosynthesis, but growing evidence also reveals that SQLE is abnormally expressed in some types of malignant tumours, even though the underlying mechanism remains poorly understood. EXPERIMENTAL APPROACH: Bioinformatics analysis and RNA sequencing were applied to detect differentially expressed genes in clinical...

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