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Article

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?

12 Apr 2018

Abstract excerpt

Chronic infection with the hepatitis B virus (HBV) is a global health concern and accounts for approximately 1 million deaths annually. Amongst other limitations of current anti-HBV treatment, failure to eliminate the viral covalently closed circular DNA (cccDNA) and emergence of resistance remain the most worrisome. Viral rebound from latent episomal cccDNA reservoirs occurs following cessation of therapy,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29649127
DOI: 10.3390/genes9040207

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