Article

Inorganic pyrophosphate disrupts amorphous hydrated bone mineral interfaces in hypophosphatasia

2025-11-27

Abstract excerpt

Bone mineral molecular architecture is tightly regulated by the kinetics of calcium phosphate phase transformations. In the rare skeletal disease hypophosphatasia (HPP), caused by inactivating mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNSALP), accumulation of inorganic pyrophosphate (PPi) alters these phase dynamics. Using solid-state nuclear magnetic resonance spectroscopy and...

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Literature Corpus work: 2fb1b21e-eed2-58e7-b8bd-b7a0a70aaa11
DOI: 10.1101/2025.11.24.689921

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