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A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy

14 Jan 2021

Abstract excerpt

ABSTRACT: Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics develop excruciating pain with a variable course. Mechanisms leading to painful DPN are not completely understood and treatment options limited. We hypothesized that epigenetic modulation at the level of...

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PMID: 33492037
DOI: 10.1097/j.pain.0000000000002159

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