Article

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy

2026-01-20

Abstract excerpt

Diabetic painful neuropathy (DPN) is characterized by neuropathic pain accompanied by loss of sensory function. We hypothesized that neurodegeneration in the dorsal root ganglion (DRG) could underlie DPN progression. To address this question, we performed multi-omic evaluation on DRGs from otherwise healthy organ donors, donors with diabetes but no neuropathy, and donors with clinically diagnosed DPN. We discovere...

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Literature Corpus work: 71f0e281-3056-5c63-adb2-8784105d3c84
DOI: 10.64898/2026.01.16.700028

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