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Article

Eliminating antibody polyreactivity through addition of N-linked glycosylation.

Protein science : a publication of the Protein Society - 1 Jun 2015

Chuang Gwo-Yu, Zhang Baoshan, McKee Krisha, O'Dell Sijy, Kwon Young Do, Zhou Tongqing, Blinn Julie, Lloyd Krissey, Parks Robert, Von Holle Tarra, Ko Sung-Youl, Kong Wing-Pui, Pegu Amarendra, Wang Keyun, Baruah Kavitha, Crispin Max, Mascola John R, Moody M Anthony, Haynes Barton F, Georgiev Ivelin S, Kwong Peter D

Abstract excerpt

Antibody polyreactivity can be an obstacle to translating a candidate antibody into a clinical product. Standard tests such as antibody binding to cardiolipin, HEp-2 cells, or nuclear antigens provide measures of polyreactivity, but its causes and the means to resolve are often unclear. Here we present a method for eliminating antibody polyreactivity through the computational design and genetic addition of...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25800131
DOI: 10.1002/pro.2682
PMCID: PMC4456115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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