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Polyreactivity of antibodies from different B-cell subpopulations is determined by distinct sequence patterns of variable region

23 Nov 2023

Abstract excerpt

An antibody molecule that can bind to multiple distinct antigens is defined as polyreactive. In the present study, we performed statistical analyses to assess sequence correlates of polyreactivity of >600 antibodies cloned from different B-cell types of healthy humans. The data revealed several sequence patterns of variable regions of heavy and light immunoglobulin chains that determine polyreactivity. The most...

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PMID: 38077343
DOI: 10.3389/fimmu.2023.1266668

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