Article

<i>MARK2</i>variants cause autism spectrum disorder<i>via</i>the downregulation of WNT/β-catenin signaling pathway

2024-04-25

Abstract excerpt

MARK2 , a member of the evolutionarily conserved PAR1/MARK serine/threonine kinase family, has been identified as a novel risk gene for autism spectrum disorder (ASD) based on the enrichment of de novo loss-of-function (Lof) variants in large-scale sequencing studies of ASD individuals. However, the features shared by affected individuals and the molecular mechanism of MARK2 variants during early neural developmen...

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Literature Corpus work: d641dfa7-7f72-5a99-b299-6a283a5ddfc6
DOI: 10.1101/2024.04.24.24304501

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