Article
Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s disease
2019-01-02
Abstract excerpt
Type-1 reactions (T1Rs) are pathological inflammatory episodes and main contributors to nerve damage in leprosy. Here, we evaluate the gene-wise enrichment of rare protein altering variants in seven genes where common variants were previously associated with T1R. We selected 474 Vietnamese leprosy-patients of which 237 were T1R-affected and 237 were T1R-free matched controls. Gene-wise enrichment of nonsynonymous...
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Identifiers and source
- Literature Corpus work
- 2f5d6d54-149b-5f5a-9336-2bef7d0b11bb
- DOI
- 10.1101/507806