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Article

Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.

Scientific reports - 23 Nov 2016

Wang Dong, Zhang Deng-Feng, Feng Jia-Qi, Li Guo-Dong, Li Xiao-An, Yu Xiu-Feng, Long Heng, Li Yu-Ye, Yao Yong-Gang

Abstract excerpt

Leprosy is a chronic infectious and neurological disease caused by Mycobacterium leprae, an unculturable pathogen with massive genomic decay and dependence on host metabolism. We hypothesized that mitochondrial genes PARL and PINK1 would confer risk to leprosy. Thirteen tag SNPs of PARL and PINK1 were analyzed in 3620 individuals with or without leprosy from China. We also sequenced the entire exons of PARL,...

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Identifiers

PMID: 27876828
DOI: 10.1038/srep37086
PMCID: PMC5120299

Genes

PARL
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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