Article
A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy.
PLoS neglected tropical diseases - 1 Feb 2016
Fava Vinicius M, Manry Jérémy, Cobat Aurélie, Orlova Marianna, Van Thuc Nguyen, Ba Nguyen Ngoc, Thai Vu Hong, Abel Laurent, Alcaïs Alexandre, Schurr Erwin
Abstract excerpt
BACKGROUND: Depending on the epidemiological setting, a variable proportion of leprosy patients will suffer from excessive pro-inflammatory responses, termed type-1 reactions (T1R). The LRRK2 gene encodes a multi-functional protein that has been shown to modulate pro-inflammatory responses. Variants near the LRRK2 gene have been associated with leprosy in some but not in other studies. We hypothesized that LRRK2...
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