Article

Rhinovirus reduces the severity of subsequent respiratory viral infections by interferon-dependent and -independent mechanisms

2020-11-06

Abstract excerpt

Coinfection by unrelated viruses in the respiratory tract is common and can result in changes in disease severity compared to infection by individual virus strains. We have previously shown that inoculation of mice with rhinovirus (RV) two days prior to inoculation with a lethal dose of influenza A virus (PR8), provides complete protection against mortality and reduces morbidity. In this study, we extended that fi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 566f4cd3-a2de-5318-8fbc-331a9444e725
DOI: 10.1101/2020.11.06.371005

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rhinovirus reduces the severity of subsequent respiratory viral infections by interferon-dependent and -independent mechanismsDOI 10.1101/2020.11.06.371005Read

Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory virusesSemantic proximity Read

Comparative Transcriptomic Analysis of Rhinovirus and Influenza Virus InfectionSemantic proximity Read

Recent advances in understanding rhinovirus immunitySemantic proximity Read

Human rhinoviruses.Semantic proximity Read

Molecular pathology of emerging coronavirus infectionsSemantic proximity Read

Distinct respiratory and neurological disease phenotypes in lethal Nipah virus Malaysia versus Bangladesh infection in IFNAR knockout mice.Semantic proximity Read

The rhinovirus puzzle: Linking virus and host factors to childhood asthma.Semantic proximity Read

Upper Airway Gene Expression in Hospitalized Children with Rhinovirus-induced Respiratory IllnessesSemantic proximity Read

Early-life heterologous rhinovirus infections induce an exaggerated asthma-like phenotype.Semantic proximity Read

Animal Pneumoviruses: Molecular Genetics and PathogenesisSemantic proximity Read

Phylogenetic Reconstruction and Homology Modeling Reveal Genotypic Diversity and Immune Dysregulation in Children with Rhinovirus- Associated PneumoniaSemantic proximity Read

Human rhinovirus recognition in non-immune cells is mediated by<i>Toll</i>-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune responseSemantic proximity Read