Article
A mouse model for studying viscerotropic disease caused by yellow fever virus infection.
PLoS pathogens - 1 Oct 2009
Meier Kathryn C, Gardner Christina L, Khoretonenko Mikhail V, Klimstra William B, Ryman Kate D
Abstract excerpt
Mosquito-borne yellow fever virus (YFV) causes highly lethal, viscerotropic disease in humans and non-human primates. Despite the availability of efficacious live-attenuated vaccine strains, 17D-204 and 17DD, derived by serial passage of pathogenic YFV strain Asibi, YFV continues to pose a significant threat to human health. Neither the disease caused by wild-type YFV, nor the molecular determinants of vaccine...
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