Article

A new screening assay reveals that aminoglycoside antibiotics interfere with the Tau/MDM2 interaction

2024-10-25

Abstract excerpt

MAPT gene mutations cause some neurodegenerative tauopathies and the MAPT -encoded protein Tau is deposited in neurofibrillary tangles, hallmarks of this disease family. In addition to its canonical function in regulating microtubule dynamics, Tau modulates chromatin compaction, gene expression, and the cellular response to DNA damage. During the DNA damage response, Tau positively modulates P53 by binding to MDM...

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Literature Corpus work: 2f3fa94c-27aa-5a7e-9eaf-f1e757a8d2fb
DOI: 10.1101/2024.10.24.619988

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