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Article

PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin

31 Jan 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Targeting microtubules is the most effective wide-spectrum pharmacological strategy in antitumoral chemotherapy, and current research focuses on reducing main drawbacks: neurotoxicity and resistance. PM534 is a novel synthetic compound derived from the Structure–Activity-Relationship study on the natural molecule PM742, isolated from the sponge of the order...

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PMID: 38294341
DOI: 10.1021/acs.jmedchem.3c01775

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