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Tau protein binds to the P53 E3 ubiquitin ligase MDM2

23 Jun 2023

Abstract excerpt

Tau gene mutations cause a progressive dementia and neurotoxic Tau forms deposited in neurofibrillary tangles are hallmarks of neurodegenerative tauopathies. Loss of non-canonical Tau functions may contribute to disease. In fact, Tau depletion affects the cellular response to DNA damage and tauopathies exhibit the accumulation of DNA lesions. Moreover, Tau modulates P53 activity and cell fate. Considering that...

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PMID: 37353565
DOI: 10.1038/s41598-023-37046-8

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