Article

Systematic morphological profiling of human gene and allele function reveals Hippo-NF-κB pathway connectivity

2016-12-08

Abstract excerpt

We hypothesized that human genes and disease-associated alleles might be systematically functionally annotated using morphological profiling of cDNA constructs, via a microscopy-based Cell Painting assay. Indeed, 50% of the 220 tested genes yielded detectable morphological profiles, which grouped into biologically meaningful gene clusters consistent with known functional annotation (e.g., the RAS-RAF-MEK-ERK casca...

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Literature Corpus work: 2f1101f6-261c-58d3-a456-2007b84e0fad
DOI: 10.1101/092403

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