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High-content microscopy and machine learning characterize a cell morphology signature of <i>NF1</i> genotype in Schwann cells

2024-09-16

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a multi-system, autosomal dominant genetic disorder driven by the systemic loss of the NF1 protein neurofibromin. Loss of neurofibromin in Schwann cells is particularly detrimental, as the acquisition of a ‘second-hit’ (e.g., complete loss of NF1 ) can lead to the development of plexiform neurofibromas (pNF). pNFs are painful, disfiguring tumors with an approximately 1 in 5 chanc...

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Literature Corpus work
556e99a5-1dee-575f-8f57-3b4e8c564b01
DOI
10.1101/2024.09.11.612546
Open publication

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High-content microscopy and machine learning characterize a cell morphology signature of <i>NF1</i> genotype in Schwann cellsDOI 10.1101/2024.09.11.612546
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