Article

The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar

2020-09-02

Abstract excerpt

<title>Abstract</title> <p>Background Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is largely limited in mammals. There, MCs undergo reactive gliosis that consist of a hypertrophic response and ultimately results in vision loss. Transforming growth factor β (TGFβ) is essential for wound healing, including both scar formation and regeneration. However, targeting TGFβ may affect other p...

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Literature Corpus work: 2eef22b9-527b-5a46-a587-664eb70210da
DOI: 10.21203/rs.3.rs-66116/v1

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