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Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina

13 Jun 2024

Abstract excerpt

Zebrafish possess the ability to regenerate dying neurons in response to retinal injury, with both Müller glia and microglia playing integral roles in this response. Resident Müller glia respond to damage by reprogramming and undergoing an asymmetric cell division to generate a neuronal progenitor cell, which continues to proliferate and differentiate into the lost neurons. In contrast, microglia become reactive,...

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PMID: 38938553
DOI: 10.3389/fcell.2024.1406330

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