Article

KRAS Inhibition Activates an Actionable CD24 “Don’t Eat Me” Signal in Pancreatic Cancer

2023-09-23

Abstract excerpt

KRAS G12C inhibitors (G12Ci) have produced encouraging, albeit modest and transient, clinical benefit in pancreatic ductal adenocarcinoma (PDAC). Identifying and targeting resistance mechanisms to G12Ci treatment is therefore crucial. To better understand the function of KRAS G12C and possible G12Ci bypass mechanisms, we developed an autochthonous KRAS G12C - driven PDAC model. Compared to the classical KRAS G...

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Literature Corpus work: 8cc2e9dc-21c4-5a61-96b9-e75f6c9e0ff6
DOI: 10.1101/2023.09.21.558891

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