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Article

Structural dynamics and allosteric communication of a SARS-like bat coronavirus spike glycoprotein.

Biophysical journal - 18 Aug 2026

Balogun Toheeb A, Kearns Fiona L, Calvó-Tusell Carla, Tse Alexandra L, Acreman Cory M, Casalino Lorenzo, Lasso Gorka, Miller Emily Happy, Chandran Kartik, McLellan Jason S, Amaro Rommie E

Abstract excerpt

SARS-like bat coronaviruses (CoVs) pose ongoing public health risks due to their zoonotic potential, making it important to understand the molecular pathways that drive their evolution. We recently showed that SHC014-CoV can infect human cell lines in an angiotensin-converting enzyme 2 (ACE2)-dependent manner after acquiring two spike ectodomain mutations (F294L and A835D). However, how the wild-type (WT) SHC014...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42026866
DOI: 10.1016/j.bpj.2026.04.023
PMCID: PMC13507448

Genes

ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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