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Article

Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2.

Scientific reports - 7 Jul 2022

Forest-Nault Catherine, Koyuturk Izel, Gaudreault Jimmy, Pelletier Alex, L'Abbé Denis, Cass Brian, Bisson Louis, Burlacu Alina, Delafosse Laurence, Stuible Matthew, Henry Olivier, De Crescenzo Gregory, Durocher Yves

Abstract excerpt

Several key mutations in the Spike protein receptor binding domain (RBD) have been identified to influence its affinity for the human Angiotensin-Converting Enzyme 2 (ACE2). Here, we perform a comparative study of the ACE2 binding to the wild type (Wuhan) RBD and some of its variants: Alpha B.1.1.7, Beta B.1.351, Delta B.1.617.2, Kappa B.1.617.1, B.1.1.7 + L452R and Omicron B.1.1.529. Using a coiled-coil mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35798770
DOI: 10.1038/s41598-022-15215-5
PMCID: PMC9261887

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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