Article

A Cdh3-Lam332 signaling axis in a leader cell subpopulation controls protrusion dynamics and tumor organoid collective migration

2022-05-10

Abstract excerpt

Carcinoma dissemination can occur when heterogeneous tumor and tumor stromal cells clusters migrate together via collective migration. Cells at the front lead and direct collective migration, yet how these leader cells form and interact with the microenvironment to direct migration are not fully appreciated. From live videos of primary mouse and human breast tumor organoids in a 3D microfluidic system that mimics...

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Literature Corpus work: 2ecf4da1-1a25-52e4-a79f-e137046d6ac8
DOI: 10.1101/2022.05.10.491382

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