Article

Targeting temporal dynamics of microenvironmental factors halts tumor migration and alleviates effects of dynamic tumor heterogeneity

2017-09-20

Abstract excerpt

<h4>Summary</h4> Targeting microenvironmental factors that foster migratory cell phenotypes is a promising strategy for halting tumor migration. However, lack of mechanistic understanding of the process impedes pharmaceutical drug development. Using a novel 3D microtumor model with tight control over tumor size, we recapitulated tumor size-induced hypoxic microenvironment and emergence of migratory phenotypes in...

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Literature Corpus work: 0e07f95f-13fb-5b38-bbe0-83a6a360fb36
DOI: 10.1101/191221

Open publication

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