Article

Matrix obstructions cause multiscale disruption in collective epithelial migration by suppressing physical function of leader cells

2022-04-29

Abstract excerpt

Cellular forces and intercellular cooperation generate collective cell migration. Pathological changes in cell-level genetic and physical properties cause jamming, unjamming, and scattering in epithelial migration. Separately, changes in microenvironment stiffness and confinement can produce varying modes of cell migration. However, it remains unclear whether and how mesoscale disruptions in matrix topology alter...

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Literature Corpus work: 8d7cfb6a-35d5-57f1-99eb-1b536d46ca97
DOI: 10.1101/2022.04.28.489943

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