Article

X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

2022-09-01

Abstract excerpt

<h4>Summary</h4> Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. We determined that female mice are more susceptible than males to glucose intolerance, fasting hyperglycemia, and muscle weakness after short-term statin treatment. Lipidomic, transcriptom...

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Literature Corpus work: 2ec707ae-82a0-5545-807f-d9dd75c2fc12
DOI: 10.1101/2022.08.29.505759

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