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Article

Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators.

Cardiovascular research - 17 Feb 2024

Kühnisch Jirko, Theisen Simon, Dartsch Josephine, Fritsche-Guenther Raphaela, Kirchner Marieluise, Obermayer Benedikt, Bauer Anna, Kahlert Anne-Karin, Rothe Michael, Beule Dieter, Heuser Arnd, Mertins Philipp, Kirwan Jennifer A, Berndt Nikolaus, MacRae Calum A, Hubner Norbert, Klaassen Sabine

Abstract excerpt

AIMS: Mutation of the PRDM16 gene causes human dilated and non-compaction cardiomyopathy. The PRDM16 protein is a transcriptional regulator that affects cardiac development via Tbx5 and Hand1, thus regulating myocardial structure. The biallelic inactivation of Prdm16 induces severe cardiac dysfunction with post-natal lethality and hypertrophy in mice. The early pathological events that occur upon Prdm16...

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Identifiers

PMID: 37842925
DOI: 10.1093/cvr/cvad154
PMCID: PMC10874277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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