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Nasal administration of Protollin enhances monocyte phagocytosis and decreases CD8+ T cell cytotoxicity in subjects with early Alzheimer’s disease: A phase 1 clinical trial

2025-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Protollin, a nasal adjuvant, was evaluated in a randomized double-blind phase 1 study of 16 early Alzheimer’s disease (AD) patients to determine safety and to assess its immunomodulatory effects. In a double-blind dose escalation study, subjects received nasal Protollin at doses of 0.1mg, 0.5mg, 1.0mg, and 1.5mg or placebo twice over a two-week period. Treatment was well-tolerated with minimal s...

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Literature Corpus work
2ec641a4-f2a6-53c7-ba91-4dbd1f9a5455
DOI
10.1101/2025.11.05.25339599
Open publication

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Nasal administration of Protollin enhances monocyte phagocytosis and decreases CD8+ T cell cytotoxicity in subjects with early Alzheimer’s disease: A phase 1 clinical trialDOI 10.1101/2025.11.05.25339599
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