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Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

14 Aug 2008

Abstract excerpt

Mutant dwarf and calorie-restricted mice benefit from healthy aging and unusually long lifespan. In contrast, mouse models for DNA repair-deficient progeroid syndromes age and die prematurely. To identify mechanisms that regulate mammalian longevity, we quantified the parallels between the genome-wide liver expression profiles of mice with those two extremes of lifespan. Contrary to expectation, we find...

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PMID: 18704162
DOI: 10.1371/journal.pgen.1000161

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