Article

Deletions of distant regulatory sequences upstream of zebrafish <i>pitx2</i> result in a range of ocular phenotypes

2019-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Development of the anterior segment of the vertebrate eye is a highly coordinated process. Genetic mutations in factors guiding this process result in Anterior Segment Dysgenesis (ASD), a spectrum of disorders affecting the iris, cornea, trabecular meshwork and/or other iridocorneal angle structures and associated with glaucoma. One of the first factors linked to ASD in humans was PITX2 , a hom...

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Literature Corpus work: 92ab6588-8471-5011-a81b-8bc81a6e82e3
DOI: 10.1101/772426

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