Article

Sex-dependent transcriptional control of cardiac electrophysiology by histone acetylation modifiers based on the GTEx database

2022-04-19

Abstract excerpt

Development of safer drugs based on epigenetic modifiers, e.g. histone deacetylase inhibitors (HDACi), requires better understanding of their effects on cardiac electrophysiology. Using RNAseq data from the genotype-tissue-expression database (GTEx), we created models that link the abundance of chromatin modifiers, such as histone acetylation enzymes (HDAC/SIRT/HATs), and the gene expression of ion channels (IC) v...

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Literature Corpus work: 2e9d0cd2-4897-5f1d-b6cc-18a6c3ba3834
DOI: 10.1101/2022.04.19.488752

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