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Article

The Metabolically Obese, Normal-Weight Phenotype in Young Rats Is Associated with Cognitive Impairment and Partially Preventable with Leptin Intake during Lactation.

International journal of molecular sciences - 22 Dec 2023

Cifre Margalida, Palou Andreu, Oliver Paula

Abstract excerpt

The intake of high-fat diets (HFDs) and obesity are linked to cognitive impairment. Here, we aimed to investigate whether an early metabolically obese, normal-weight (MONW) phenotype, induced with an HFD in young rats, also leads to cognitive dysfunction and to evaluate the potential cognitive benefits of neonatal intake of leptin. To achieve this, Wistar rats orally received physiological doses of leptin or its...

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Identifiers

PMID: 38203399
DOI: 10.3390/ijms25010228
PMCID: PMC10778589

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