Article

Tetraploidization-driven PRKG1 deletion reveals novel mechanisms underlying Leiomyosarcoma aggressiveness

2025-07-23

Abstract excerpt

<title>Abstract</title> <p> Leiomyosarcoma (LMS) is a malignant mesenchymal tumor with smooth muscle cell (SMC) differentiation. LMS shows high metastatic rate and highly rearranged genome, associated with whole genome doubling, which is identified in more than half of cases. We tested the hypothesis that cell fusion could be one of the mechanisms involved in the development of genome doubling and the production...

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Literature Corpus work: 2e8a7b89-cf56-5a40-bb8e-ae78dcbf0002
DOI: 10.21203/rs.3.rs-6984264/v1

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