Article
Characterization of uterine leiomyomas by whole-genome sequencing.
The New England journal of medicine - 4 Jul 2013
Mehine Miika, Kaasinen Eevi, Mäkinen Netta, Katainen Riku, Kämpjärvi Kati, Pitkänen Esa, Heinonen Hanna-Riikka, Bützow Ralf, Kilpivaara Outi, Kuosmanen Anna, Ristolainen Heikki, Gentile Massimiliano, Sjöberg Jari, Vahteristo Pia, Aaltonen Lauri A
Abstract excerpt
BACKGROUND: Uterine leiomyomas are benign but affect the health of millions of women. A better understanding of the molecular mechanisms involved may provide clues to the prevention and treatment of these lesions. METHODS: We performed whole-genome sequencing and gene-expression profiling of 38 uterine leiomyomas and the corresponding myometrium from 30 women. RESULTS: Identical variants observed in some separate...
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