Article

Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation

2023-09-20

Abstract excerpt

<title>Abstract</title><p>DEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be elucidated. Here, we discovered a novel mechanism by which DDX41 contributes to R-loop-induced DNA damage responses (DDR) in cooperation with the m6A-METTL complex (MAC) and YTHDC1 us...

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Literature Corpus work: 2e750bc8-cc50-51db-a595-bd1311bdd841
DOI: 10.21203/rs.3.rs-3350496/v1

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