Article
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation.
Leukemia - 1 Jun 2024
Hwang Won Chan, Park Kibeom, Park Silvia, Cheon Na Young, Lee Ja Yil, Hwang Taejoo, Lee Semin, Lee Jong-Mi, Ju Min Kyung, Lee Joo Rak, Kwon Yong-Rim, Jo Woo-Lam, Kim Myungshin, Kim Yoo-Jin, Kim Hongtae
Abstract excerpt
DEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be elucidated. Here, we discovered a novel mechanism by which DDX41 contributes to R-loop-induced DNA damage responses (DDR) in cooperation with the m6A-METTL complex (MAC) and YTHDC1 using DDX41 knockout (KO)...
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