Article

DDX41 coordinates RNA splicing and transcriptional elongation to prevent DNA replication stress in hematopoietic cells

2022-07-29

Abstract excerpt

<title>Abstract</title> <p>Myeloid malignancies with <italic>DDX41</italic> mutations are often associated with bone marrow failure and cytopenia before overt disease manifestation. However, the mechanisms underlying these specific conditions remain elusive. Here, we demonstrate that loss of DDX41 function impairs efficient RNA splicing, resulting in DNA replication stress with excess R-loop formation. Mechanisti...

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Literature Corpus work: b0db70ed-5a76-5552-9cf2-224c1440043e
DOI: 10.21203/rs.3.rs-1849709/v1

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