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Article

BMP signaling in vascular diseases

3 May 2012

Abstract excerpt

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family that signal via type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. BMPs are multifunctional regulators of development and tissue homeostasis and they were initially characterized as inducers of bone regeneration. Genetic studies in humans and mice showed that...

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PMID: 22710160
DOI: 10.1016/j.febslet.2012.04.030

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