Article

A phenotype-based cell culture model of melanoma cells that persist as residual disease after therapies leading to recurrence

2026-02-18

Abstract excerpt

<title>Abstract</title> A crucial adaptability trait of stem-like melanoma cells that persist under all selection pressures, including therapies, is their ability to survive in deep quiescence. This ability coupled with their intrinsic ability to proliferate leads to recurrence. Here we describe an approach to modeling this trait in cell culture. A lack of glutamine proved to be a selection pressure for the hi...

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Literature Corpus work: 2e4ec1da-3160-5c24-bf7c-24453bfc602a
DOI: 10.21203/rs.3.rs-8768856/v1

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