Article
The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases.
Archives of biochemistry and biophysics - 15 Oct 2021
D'Errico Mariarosaria, Parlanti Eleonora, Pascucci Barbara, Filomeni Giuseppe, Mastroberardino Pier Giorgio, Dogliotti Eugenia
Abstract excerpt
As mitochondria are vulnerable to oxidative damage and represent the main source of reactive oxygen species (ROS), they are considered key tuners of ROS metabolism and buffering, whose dysfunction can progressively impact neuronal networks and disease. Defects in DNA repair and DNA damage response (DDR) may also affect neuronal health and lead to neuropathology. A number of congenital DNA repair and DDR defective...
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