Article

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization

2020-07-22

Abstract excerpt

Human ether - à - go - go -related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. Although it is known that APETx1 inhibits hERG by stabilizing the resting state, it remains unclear where and how APETx1 interacts with the VSD in the resting state. Here, we prepared a recombinant APETx1, which is str...

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Literature Corpus work: 2e2bd359-5bad-5296-83a4-624b8de8be20
DOI: 10.1101/2020.07.22.215491

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