Article

NADPH phosphatase activity of Mesh1 controls sleep in <i>Drosophila</i>

2025-12-16

Abstract excerpt

Recent findings have shown that metazoans accumulate the bacterial second messenger guanosine tetraphosphate (ppGpp) and possess Mesh1 , a gene encoding a ppGpp hydrolase domain. Mesh1 deficiency affects sleep behavior and eclosion under starvation in Drosopila , and ferroptosis in human cells. However, human Mesh1 also exhibits NADPH/NADP + phosphatase activity in vitro, making it unclear whether these phenot...

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Literature Corpus work: 2e241661-3fbc-5425-959a-3ee7519ca72f
DOI: 10.64898/2025.12.14.694245

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