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The <i>C. elegans</i> homolog of <i>TMEM132D</i> , a human panic-disorder and anxiety risk gene, modulates neuronal morphogenesis through the WAVE-regulatory complex

2020-11-17

Abstract excerpt

<h4>SUMMARY</h4> TMEM132D is a human gene identified with multiple risk alleles for panic disorders, anxiety and major depressive disorders. Belonging to a conserved family of transmembrane proteins, TMEM132D and its homologs are still of unknown molecular functions. By generating loss-of-function mutants of the sole TMEM132 ortholog in C. elegans , we identify abnormal morphologic phenotypes in the dopaminergic...

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Literature Corpus work
a3a8a42f-c8bd-5901-8db8-4c2e458d4f85
DOI
10.1101/2020.11.16.385906
Open publication

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The <i>C. elegans</i> homolog of <i>TMEM132D</i> , a human panic-disorder and anxiety risk gene, modulates neuronal morphogenesis through the WAVE-regulatory complexDOI 10.1101/2020.11.16.385906
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